Chimiothèques de complexes du technétium et du rhénium ciblant l'intégrine alphaVbeta3 : développement de traceurs pour la détection précoce de la néoangiogenèse tumorale

Chimiothèques de complexes du technétium et du rhénium ciblant l'intégrine alphaVbeta3 : développement de traceurs pour la détection précoce de la néoangiogenèse tumorale

Les intégrines sont des protéines membranaires hétérodimériques impliquées dans l'adhésion et la migration cellulaire. Elles sont notamment surexprimées lors de la néoangiogenèse tumorale. Une dizaine d'entre elles reconnaît un motif peptidique RGD (Arg-Gly-Asp) structuré. Des analogues de...

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Bibliographic Details
Main Author:	Aufort, Marie
Language:	FRE
Published:	Université Paris Sud - Paris XI 2008
Subjects:	[SDV:SP:MED] Life Sciences/Pharmaceutical sciences/Medication rhénium technétium chimie combinatoire cancer integrine imagerie moléculaire in vivo
Online Access:	http://tel.archives-ouvertes.fr/tel-00339820 http://tel.archives-ouvertes.fr/docs/00/33/98/20/PDF/these_aufort.pdf

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