Comparative studies of Vulva development in C. briggsae
<p>As evolution progresses, developmental changes occur. Genes lose and gain molecular partners, regulatory sequences, and new functions. As a consequence, tissues evolve alternative methods to develop similar structures, more or less robust. How this occurs is a major question in biology....
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| Format: | Others |
| Language: | en |
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2001
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| Online Access: | https://thesis.library.caltech.edu/8108/1/Brown_kb_2001.pdf Brown, Keith B. (2001) Comparative studies of Vulva development in C. briggsae. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/n37e-5g80. https://resolver.caltech.edu/CaltechTHESIS:03062014-111730488 <https://resolver.caltech.edu/CaltechTHESIS:03062014-111730488> |
| Summary: | <p>As evolution progresses, developmental changes occur. Genes lose and gain
molecular partners, regulatory sequences, and new functions. As a consequence, tissues
evolve alternative methods to develop similar structures, more or less robust. How this
occurs is a major question in biology. One method of addressing this question is by
examining the developmental and genetic differences between similar species. Several
studies of nematodes Pristionchus pacificus and Oscheius CEW1 have revealed various
differences in vulval development from the well-studied C. elegans (e.g. gonad induction,
competence group specification, and gene function.)</p>
<p>I approached the question of developmental change in a similar manner by using
Caenorhabditis briggsae, a close relative of C. elegans. C. briggsae allows the use of
transgenic approaches to determine developmental changes between species. We
determined subtle changes in the competence group, in 1° cell specification, and vulval
lineage.</p>
<p>We also analyzed the let-60 gene in four nematode species. We found
conservation in the codon identity and exon-intron boundaries, but lack of an extended 3'
untranslated region in Caenorhabditis briggsae.</p> |
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