Synthesis and Biological Studies of DNA-binding Cyclic Py-Im Polyamides

Synthesis and Biological Studies of DNA-binding Cyclic Py-Im Polyamides

Pyrrole-imidazole (Py-Im) polyamides are programmable oligomers that bind to the minor groove of DNA in a sequence-specific manner at affinities comparable to natural DNA-binding proteins. Hairpin polyamides have been shown to localize within the nucleus of live cells, disrupt protein-DNA interactio...

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Bibliographic Details
Main Author: Li, Benjamin Chun Yeung
Format: Others
Published: 2013
Online Access:https://thesis.library.caltech.edu/7496/1/BenLi%20Thesis%20Final%20Edit.pdf
Li, Benjamin Chun Yeung (2013) Synthesis and Biological Studies of DNA-binding Cyclic Py-Im Polyamides. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/82YX-QB29. https://resolver.caltech.edu/CaltechTHESIS:02282013-171348639 <https://resolver.caltech.edu/CaltechTHESIS:02282013-171348639>

Internet

https://thesis.library.caltech.edu/7496/1/BenLi%20Thesis%20Final%20Edit.pdf
Li, Benjamin Chun Yeung (2013) Synthesis and Biological Studies of DNA-binding Cyclic Py-Im Polyamides. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/82YX-QB29. https://resolver.caltech.edu/CaltechTHESIS:02282013-171348639 <https://resolver.caltech.edu/CaltechTHESIS:02282013-171348639>

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