I. Thermal cyclization of (Z)-1,2,4-heptatrien-6-yne. II. Studies directed toward the synthesis of neocarzinostatin chromophore
<p>The possibility that the hydrocarbon (Z)-1,2,4-heptatrien-6-yne might undergo a thermal cyclization to the biradical α,3-dehydroluene was considered. A methodology for the synthesis of (Z)-1,2,4-heptatrien-6-yne was developed wherein propargyl hydrazines, obtained from the corresponding...