Structure-Function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids and Synthetic Agonist Analogs
<p>This dissertation primarily describes structure-function studies of the prototypical Cys-loop ligand-gated ion channel, the nicotinic acetylcholine receptors (nAChRs).</p> <p>Agonists that bind nAChRs, including acetylcholine, nicotine, and the smoking cessation drug varenic...