Biological Activity of a Py-Im Polyamide Androgen Receptor Antagonist
Py-Im polyamides are cell-permeable, programmable, sequence-specific, DNA minor groove-binding small molecules. When designed to bind a DNA sequence that matches the consensus DNA-binding sequence of a transcription factor, they can be used to block the binding of that transcription factor to its r...
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https://thesis.library.caltech.edu/6493/2/02_Phillips_Ch1_Intro.pdf
https://thesis.library.caltech.edu/6493/3/03_Phillips_Ch2_Library.pdf
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Phillips, John Wilson (2011) Biological Activity of a Py-Im Polyamide Androgen Receptor Antagonist. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/MPH7-D492. https://resolver.caltech.edu/CaltechTHESIS:06022011-172257819 <https://resolver.caltech.edu/CaltechTHESIS:06022011-172257819>