Computational Challenges in High-Resolution Cryo-Electron Microscopy
<p>To avoid the challenges of crystallization and the size limitations of NMR, it has long been hoped that single-particle cryo-electron microscopy (cryo-EM) would eventually yield atomically interpretable reconstructions. For the most favorable class of specimens (large icosahedral viruses),...
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https://thesis.library.caltech.edu/5245/7/PeterLeongThesis.pdfhttps://thesis.library.caltech.edu/5245/1/00Title.pdf
https://thesis.library.caltech.edu/5245/2/01Introduction.pdf
https://thesis.library.caltech.edu/5245/3/02Peach.pdf
https://thesis.library.caltech.edu/5245/4/03Prec.pdf
https://thesis.library.caltech.edu/5245/5/04Conclusion.pdf
https://thesis.library.caltech.edu/5245/6/05Appendix.pdf
Leong, Peter Anthony (2009) Computational Challenges in High-Resolution Cryo-Electron Microscopy. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/GJKS-2P80. https://resolver.caltech.edu/CaltechETD:etd-08072008-171049 <https://resolver.caltech.edu/CaltechETD:etd-08072008-171049>