The design, synthesis, and evolution of macrocyclic mRNA display libraries containing unnatural amino acids
Combinatorial design is a powerful method for generating ligands that disrupt protein-protein interactions, particularly in the absence of structural information. mRNA display is powerful in vitro biological display technique that enables the synthesis and evolution of trillion-member peptide libra...
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https://thesis.library.caltech.edu/5187/1/MillwardChapter1.pdfhttps://thesis.library.caltech.edu/5187/2/MillwardChapter2.pdf
https://thesis.library.caltech.edu/5187/3/MillwardChapter3.pdf
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https://thesis.library.caltech.edu/5187/6/MillwardIntroduction.pdf
Millward, Steven Wesley (2007) The design, synthesis, and evolution of macrocyclic mRNA display libraries containing unnatural amino acids. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/THV4-2A51. https://resolver.caltech.edu/CaltechETD:etd-05142007-161158 <https://resolver.caltech.edu/CaltechETD:etd-05142007-161158>