Engineering protein glycosylation in Chinese hamster ovary cells : genetic manipulations, global glycoprotein analysis, and studies of environmental influences
The ability to engineer the glycosylation of proteins, and particularly recombinant proteins, would be of great benefit in the study and production of glycoproteins. One way to alter glycosylation is to genetically manipulate glycosyltransferase expression in a host cell. Two approaches of genetic m...