Completion of a Programmable DNA-Binding Small Molecule Library
Hairpin pyrrole-imidazole (Py-Im) polyamides are programmable oligomers that bind the DNA minor groove in a sequence-specific manner with affinities comparable to those of natural DNA-binding proteins. These cell-permeable small molecules have been shown to enter the nuclei of live cells and downre...
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https://thesis.library.caltech.edu/4398/5/05_Chapter_4A.pdf
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https://thesis.library.caltech.edu/4398/7/07_Chapter_5.pdf
https://thesis.library.caltech.edu/4398/8/08_Appendix.pdf
Hsu, Carey Frank (2009) Completion of a Programmable DNA-Binding Small Molecule Library. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/PG0R-3X44. https://resolver.caltech.edu/CaltechETD:etd-11032008-191338 <https://resolver.caltech.edu/CaltechETD:etd-11032008-191338>