Dihydrofolate reductase gene amplification in human cell lines VA2-B and hela BU25

Dihydrofolate reductase gene amplification in human cell lines VA2-B and hela BU25

Mammalian gene amplification has been studied using as a model system the amplification of the endogenous Dihydrofolate Reductase (DHFR) gene in the human cell lines VA[subscript 2]-B and Hela BU25. Cell lines were stepwise-selected to high DHFR gene copy number using methotrexate, a DHFR enzyme inh...

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Bibliographic Details
Main Author: Maurer, Barry James
Format: Others
Language:en
Published: 1995
Online Access:https://thesis.library.caltech.edu/4219/1/Maurer_bj_1995.pdf
Maurer, Barry James (1995) Dihydrofolate reductase gene amplification in human cell lines VA2-B and hela BU25. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/pfsj-xf27. https://resolver.caltech.edu/CaltechETD:etd-10232007-082738 <https://resolver.caltech.edu/CaltechETD:etd-10232007-082738>

Internet

https://thesis.library.caltech.edu/4219/1/Maurer_bj_1995.pdf
Maurer, Barry James (1995) Dihydrofolate reductase gene amplification in human cell lines VA2-B and hela BU25. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/pfsj-xf27. https://resolver.caltech.edu/CaltechETD:etd-10232007-082738 <https://resolver.caltech.edu/CaltechETD:etd-10232007-082738>

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