Directed Evolution of Biosynthetic Pathways to Carotenoids with Unnatural Carbon Backbones
<p>Over the course of evolution, nature continually discovers new small molecules through the alteration of biosynthetic enzymes and pathways by mutation and gene transfer. Hundreds of these natural products have proven indispensable to medicine, culture, and technology, greatly contributing t...
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https://thesis.library.caltech.edu/3201/1/00-Tobias_Whole_Thesis.pdfhttps://thesis.library.caltech.edu/3201/2/01-Tobias_Title_Section.pdf
https://thesis.library.caltech.edu/3201/3/02-Tobias_Chapter_1.pdf
https://thesis.library.caltech.edu/3201/4/03-Tobias_Chapter_2.pdf
https://thesis.library.caltech.edu/3201/5/04-Tobias_Chapter_3.pdf
https://thesis.library.caltech.edu/3201/6/05-Tobias_Appendix_A.pdf
Tobias, Alexander Vincent (2006) Directed Evolution of Biosynthetic Pathways to Carotenoids with Unnatural Carbon Backbones. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/WF0Q-2J98. https://resolver.caltech.edu/CaltechETD:etd-08232005-174620 <https://resolver.caltech.edu/CaltechETD:etd-08232005-174620>