The Tethered Agonist Approach to Mapping Ion-Channel Proteins: Toward a Structural Model for the Agonist-Binding Site of the Nicotinic Acetylcholine Receptor
<p>The integral membrane proteins of neurons and other excitable cells are generally resistant to high-resolution structural tools. In this thesis we present our efforts to probe the structure of the agonist-binding site of the nicotinic acetylcholine receptor (nAChR) using the tethered agoni...