I. Structural analogs of typical substrates of alpha-chymotrypsin. II. 1-acetyl-2-[L-tyrosyl] hydrazine : an inhibitor of alpha-chymotrypsin. III. Binuclear aromatics as inhibitors of alpha-chymotrypsin-catalyzed hydrolyses. IV. Applicability of the pH-stat to alpha-chymotrypsin-catalyzed hydrolyses that produce a buffer
Substitution of a nitrogen atom in place of the C-H group that occurs at the asymmetric center of typical substrates of alpha-chymotrypsin results in the complete loss of the ability of the enzyme to catalyze the hydrolysis of the carboethoxy or carboxamido group. However, the nitrogen-substituted a...