Enantioselective Organocatalytic Friedel-Crafts Alkylations of Heterocycles and Electron-Rich Benzenes
<p>The development of the first organocatalytic asymmetric Friedel-Crafts alkylation is described in the context of conjugate additions of pyrroles to a,b-unsaturated aldehydes. Catalytic amounts of chiral imidazolidinone salts are used to activate the electrophile component via reversible fo...