Structural Modifications to DNA-Binding Polyamides for Improved Biological Activity in Cell Culture
Polyamides are a class of synthetic small molecules that recognize DNA in a sequence-specific fashion through a network of hydrogen bonds formed with bonding partners in the floor of the minor groove. The binding affinity of polyamides is comparable to that of numerous DNA-binding proteins, and pol...
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https://thesis.library.caltech.edu/2181/2/02Acknowledgements_Abstract_Contents.pdf
https://thesis.library.caltech.edu/2181/3/03Chapter1Intro.pdf
https://thesis.library.caltech.edu/2181/4/04Chapter2.pdf
https://thesis.library.caltech.edu/2181/5/05Chapter3.pdf
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https://thesis.library.caltech.edu/2181/7/07AppendixA.pdf
https://thesis.library.caltech.edu/2181/8/08AppendixB.pdf
https://thesis.library.caltech.edu/2181/9/09AppendixC.pdf
Jacobs, Claire Sigrid (2009) Structural Modifications to DNA-Binding Polyamides for Improved Biological Activity in Cell Culture. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/HMMN-YW83. https://resolver.caltech.edu/CaltechETD:etd-05272009-161836 <https://resolver.caltech.edu/CaltechETD:etd-05272009-161836>