Development and Validation of Optimization Methods for the Design of Protein Sequences and Combinatorial Libraries
<p>To facilitate the design of protein sequences with desired properties, simulation techniques have been developed to allow large portions of amino acid sequence space to be evaluated by computer. These computational protein design methods apply optimization algorithms to sort through the eno...
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https://thesis.library.caltech.edu/1570/10/BDA-thesis-final.pdfhttps://thesis.library.caltech.edu/1570/1/00_title.pdf
https://thesis.library.caltech.edu/1570/2/01_abstract.pdf
https://thesis.library.caltech.edu/1570/3/02_tableof.pdf
https://thesis.library.caltech.edu/1570/4/03_chapter1_introduction.pdf
https://thesis.library.caltech.edu/1570/5/04_chapter2_wayfaster.pdf
https://thesis.library.caltech.edu/1570/6/05_chapter3_msdmethods.pdf
https://thesis.library.caltech.edu/1570/7/06_chapter4_msdlibraries.pdf
https://thesis.library.caltech.edu/1570/8/07_chapter5_conclusions.pdf
https://thesis.library.caltech.edu/1570/9/08_appendixI_enzymes.pdf
Allen, Benjamin Daniel (2009) Development and Validation of Optimization Methods for the Design of Protein Sequences and Combinatorial Libraries. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/SNJJ-0Q88. https://resolver.caltech.edu/CaltechETD:etd-05012009-112749 <https://resolver.caltech.edu/CaltechETD:etd-05012009-112749>