The Role of Mitofusin Proteins in Mitochondrial Fusion and Disease

The Role of Mitofusin Proteins in Mitochondrial Fusion and Disease

We have investigated the role of mitofusin proteins in mitochondrial fusion and Charcot-Marie-Tooth disease Type 2A (CMT2A). Mitofusins (Mfn1 and Mfn2) are required for mammalian mitochondrial fusion. In structure-function analysis, we have identified loss-of-function mutations in mitofusin GTPase...

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Bibliographic Details
Main Author: Detmer, Scott A.
Format: Others
Published: 2007
Online Access:https://thesis.library.caltech.edu/1376/1/detmer_thesis.pdf
Detmer, Scott A. (2007) The Role of Mitofusin Proteins in Mitochondrial Fusion and Disease. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/7MXP-WS63. https://resolver.caltech.edu/CaltechETD:etd-04132007-181115 <https://resolver.caltech.edu/CaltechETD:etd-04132007-181115>

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