Approach to the Synthesis of the Acyltetramic Acid Antibiotic Bu-2313
<p>An approach to the synthesis of the bicyclononane portion of the 3-acyltetramic acid antibiotic Bu-2313 is presented. The highly unstable α-ketoaldehyde obtained by Swern oxidation of the diol 30 was allowed to condense with the unreactive α-ketophosphoranylidene 18 affording the enedione 3...
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