I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles

I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles

<p>The preparation of each of the four optical isomers of α-amino-β-hydroxy-<i>n</i>-caproic acid is described. The configurations of the four optically active amino acids have been deduced on the basis of evidence obtained from the reactions of their N-benzoyl-O-methyl derivatives...

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Main Author: Adams, Robert Train
Format: Others
Published: 1950
Online Access:https://thesis.library.caltech.edu/11770/2/Adams_RT_1950.pdf
Adams, Robert Train (1950) I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/BWFC-9S12. https://resolver.caltech.edu/CaltechTHESIS:08292019-160935347 <https://resolver.caltech.edu/CaltechTHESIS:08292019-160935347>
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spelling ndltd-CALTECH-oai-thesis.library.caltech.edu-117702019-12-21T03:06:50Z I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles Adams, Robert Train <p>The preparation of each of the four optical isomers of α-amino-β-hydroxy-<i>n</i>-caproic acid is described. The configurations of the four optically active amino acids have been deduced on the basis of evidence obtained from the reactions of their N-benzoyl-O-methyl derivatives with <i>p</i>-toluidine in the presence of papain and evidence obtained by oxidative degradation of one of the active α-amino-β-hydroxy-<i>n</i>-caproic acids to an optically active α-hydroxyvaleric acid. The reduction of α-benzamido-β-methoxy-<i>n</i>-caproic acid with lithium aluminum hydride is described.</p> <p>Experiments directed toward the synthesis of aminomethanesulfonamide and α-aminoethanesulfonamide are reported.</p> <p>The influence of nerve impulse sequence on the contractions of different crustacean muscles has been investigated by studying the effect of intercalating extra stimuli during stimulation at a low frequency and by studying the effect of changes in the pattern of the stimulating impulses. The effect of impulse-spacing on subsequent facilitation of the contraction has been examined. The results of these investigations are described. The significance of pattern-sensitivity in synaptic structures is discussed.</p> 1950 Thesis NonPeerReviewed application/pdf https://thesis.library.caltech.edu/11770/2/Adams_RT_1950.pdf https://resolver.caltech.edu/CaltechTHESIS:08292019-160935347 Adams, Robert Train (1950) I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/BWFC-9S12. https://resolver.caltech.edu/CaltechTHESIS:08292019-160935347 <https://resolver.caltech.edu/CaltechTHESIS:08292019-160935347> https://thesis.library.caltech.edu/11770/
collection NDLTD
format Others
sources NDLTD
description <p>The preparation of each of the four optical isomers of α-amino-β-hydroxy-<i>n</i>-caproic acid is described. The configurations of the four optically active amino acids have been deduced on the basis of evidence obtained from the reactions of their N-benzoyl-O-methyl derivatives with <i>p</i>-toluidine in the presence of papain and evidence obtained by oxidative degradation of one of the active α-amino-β-hydroxy-<i>n</i>-caproic acids to an optically active α-hydroxyvaleric acid. The reduction of α-benzamido-β-methoxy-<i>n</i>-caproic acid with lithium aluminum hydride is described.</p> <p>Experiments directed toward the synthesis of aminomethanesulfonamide and α-aminoethanesulfonamide are reported.</p> <p>The influence of nerve impulse sequence on the contractions of different crustacean muscles has been investigated by studying the effect of intercalating extra stimuli during stimulation at a low frequency and by studying the effect of changes in the pattern of the stimulating impulses. The effect of impulse-spacing on subsequent facilitation of the contraction has been examined. The results of these investigations are described. The significance of pattern-sensitivity in synaptic structures is discussed.</p>
author Adams, Robert Train
spellingShingle Adams, Robert Train
I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles
author_facet Adams, Robert Train
author_sort Adams, Robert Train
title I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles
title_short I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles
title_full I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles
title_fullStr I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles
title_full_unstemmed I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles
title_sort i. the synthesis of d- and l-threo- and d- and l-erythro-α-amino-β-hydroxy-n-caproic acids. ii. experiments on the preparation of α-aminoalkanesulfonamides. iii. the influence of nerve impulse sequence on the contractions of different crustacean muscles
publishDate 1950
url https://thesis.library.caltech.edu/11770/2/Adams_RT_1950.pdf
Adams, Robert Train (1950) I. The Synthesis of D- and L-Threo- and D- and L-Erythro-α-Amino-β-hydroxy-n-caproic Acids. II. Experiments on the Preparation of α-Aminoalkanesulfonamides. III. The Influence of Nerve Impulse Sequence on the Contractions of Different Crustacean Muscles. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/BWFC-9S12. https://resolver.caltech.edu/CaltechTHESIS:08292019-160935347 <https://resolver.caltech.edu/CaltechTHESIS:08292019-160935347>
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