Subunit Selective Degradation of WIZ, a Lenalidomide- and Pomalidomide-Dependent Substrate of E3 Ubiquitin Ligase CRL4CRBN

Subunit Selective Degradation of WIZ, a Lenalidomide- and Pomalidomide-Dependent Substrate of E3 Ubiquitin Ligase CRL4CRBN

<p>This dissertation is focused on identifying novel targets of immunomodulatory(IMiD) drugs. IMiDs are a class of drugs that are used to treat multiple myeloma.The first chapter is an introduction to the clinical use of IMiDs, as well as the proteincereblon (CRBN), the primary target of IMiDs...

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Bibliographic Details
Main Author: Yu, Helen
Format: Others
Published: 2019
Online Access:https://thesis.library.caltech.edu/11485/2/yu-helen-2019-thesis.pdf
Yu, Helen (2019) Subunit Selective Degradation of WIZ, a Lenalidomide- and Pomalidomide-Dependent Substrate of E3 Ubiquitin Ligase CRL4CRBN. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Z7PK-NH81. https://resolver.caltech.edu/CaltechTHESIS:04232019-210733826 <https://resolver.caltech.edu/CaltechTHESIS:04232019-210733826>

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https://thesis.library.caltech.edu/11485/2/yu-helen-2019-thesis.pdf
Yu, Helen (2019) Subunit Selective Degradation of WIZ, a Lenalidomide- and Pomalidomide-Dependent Substrate of E3 Ubiquitin Ligase CRL4CRBN. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/Z7PK-NH81. https://resolver.caltech.edu/CaltechTHESIS:04232019-210733826 <https://resolver.caltech.edu/CaltechTHESIS:04232019-210733826>

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