Mechanistic Bases for Privileged Capture and Unidirectional Targeting of Tail-Anchored Proteins by the Get3 ATPase
<p>C-terminal tail-anchored membrane proteins (TAs) are targeted post-translationally to the endoplasmic reticulum (ER) in eukaryotic cells mainly through the Guided entry of tail-anchored protein (GET) pathway. Here we use biochemical and biophysical approaches to shed further mechanistic ins...