Ectopic expression of TAL-1 increases resistance to TNF[alpha]-induced apoptosis in Jurkat cells via changes in the NF-kB signaling pathway

Ectopic expression of TAL-1 increases resistance to TNF[alpha]-induced apoptosis in Jurkat cells via changes in the NF-kB signaling pathway

TAL-1, ectopically expressed in 60% of T-cell acute lymphoblastic leukemia (T-ALL) patients, may contribute to poor chemotherapy response. This research sought to determine if TAL-1 influences expression of proteins involved in the NF-kB signaling pathway and thus, resistance to cell death. NF-kB,...

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Bibliographic Details
Main Author: Lucas, Bethany R.
Other Authors: Olesen, James B.
Published: 2011
Subjects:
Lymphoblastic leukemia > Genetic aspects.
Tumor necrosis factor > Receptors.
NF-kappa B (DNA-binding protein)
Apoptosis.
Protein kinases > Inhibitors.
Online Access:http://cardinalscholar.bsu.edu/handle/123456789/194751
http://liblink.bsu.edu/uhtbin/catkey/1642170

Internet

http://cardinalscholar.bsu.edu/handle/123456789/194751
http://liblink.bsu.edu/uhtbin/catkey/1642170

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