H-89 inhibits transient outward (Ito) and inward rectifier (IK1) potassium currents independently of pka-mediated phosphorylation in isolated rat ventricular myocytes
No === Voltage clamp was used to investigate the effects of N-[2-p-bromo-cinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), a potent inhibitor of PKA, on transient outward K+ current (Ito) and inward rectifying K+ current (IK1) in rat cardiac muscle. Initial experiments, performed using descendi...
| Main Authors: | , , , |
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| Language: | en |
| Published: |
2009
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10454/3310 |