Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors?

No === In the November issue (2001) of Neuroscience Letters, Holmin et al. (Neurosci. Lett. 314 (2001) 151) reported that the synthesis of the intermediate filament protein nestin was upregulated by potassium-induced depolarization in the rat cortex. In this letter, we provide supplementary evidence...

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Main Authors:	Obrenovitch, Tihomir P., Chazot, P.L., Godukhin, O.V.
Language:	en
Published:	2009
Subjects:	Neuroglia Central nervous system Brain vertebrata Mammalia Rodentia Rat Mouse Gene expression Astrocyte NMDA receptor Cerebral cortex Spreading depression
Online Access:	http://hdl.handle.net/10454/3115

id	ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-3115
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spelling	ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-31152019-08-31T03:02:20Z Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors? Obrenovitch, Tihomir P. Chazot, P.L. Godukhin, O.V. Neuroglia Central nervous system Brain vertebrata Mammalia Rodentia Rat Mouse Gene expression Astrocyte NMDA receptor Cerebral cortex Spreading depression No In the November issue (2001) of Neuroscience Letters, Holmin et al. (Neurosci. Lett. 314 (2001) 151) reported that the synthesis of the intermediate filament protein nestin was upregulated by potassium-induced depolarization in the rat cortex. In this letter, we provide supplementary evidence that repeated cortical spreading depression elicited by potassium induces a delayed upregulation of nestin. However, we argue against the authors' conclusion, Nestin expression was N-methyl-D-aspartate (NMDA)-receptor dependent since dizocilpine (MK-801) treatment abolished the response because spreading depression itself is very sensitive to NMDA-receptor block, and the drug treatment was initiated prior to potassium application to the cortex in Holmin et al.'s study. 2009-07-27T09:12:24Z 2009-07-27T09:12:24Z 2002 Article No full-text available in the repository Obrenovitch, T.P., Chazot, P.L. and Godukhin, O.V. (2002). Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors? Neuroscience Letters. Vol. 320, No. 3, pp. 161-163. http://hdl.handle.net/10454/3115 en http://dx.doi.org/10.1016/S0304-3940(02)00046-0
collection	NDLTD
language	en
sources	NDLTD
topic	Neuroglia Central nervous system Brain vertebrata Mammalia Rodentia Rat Mouse Gene expression Astrocyte NMDA receptor Cerebral cortex Spreading depression
spellingShingle	Neuroglia Central nervous system Brain vertebrata Mammalia Rodentia Rat Mouse Gene expression Astrocyte NMDA receptor Cerebral cortex Spreading depression Obrenovitch, Tihomir P. Chazot, P.L. Godukhin, O.V. Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors?
description	No === In the November issue (2001) of Neuroscience Letters, Holmin et al. (Neurosci. Lett. 314 (2001) 151) reported that the synthesis of the intermediate filament protein nestin was upregulated by potassium-induced depolarization in the rat cortex. In this letter, we provide supplementary evidence that repeated cortical spreading depression elicited by potassium induces a delayed upregulation of nestin. However, we argue against the authors' conclusion, Nestin expression was N-methyl-D-aspartate (NMDA)-receptor dependent since dizocilpine (MK-801) treatment abolished the response because spreading depression itself is very sensitive to NMDA-receptor block, and the drug treatment was initiated prior to potassium application to the cortex in Holmin et al.'s study.
author	Obrenovitch, Tihomir P. Chazot, P.L. Godukhin, O.V.
author_facet	Obrenovitch, Tihomir P. Chazot, P.L. Godukhin, O.V.
author_sort	Obrenovitch, Tihomir P.
title	Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors?
title_short	Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors?
title_full	Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors?
title_fullStr	Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors?
title_full_unstemmed	Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors?
title_sort	repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. is this upregulation initiated by n-methyl-d-aspartate receptors?
publishDate	2009
url	http://hdl.handle.net/10454/3115
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Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors?

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