In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance

In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance

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Yes === Platinum drugs are widely used for cancer treatment. Other precious metals are promising, but their clinical progress depends on achieving different mechanisms of action to overcome Pt-resistance. Here, we evaluate 13 organo-Os complexes: 16-electron sulfonyl-diamine catalysts [(η6-arene)Os(...

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Bibliographic Details
Main Authors: Coverdale, J.P.C., Bridgewater, H.E., Song, J.-I., Smith, N.A., Barry, Nicolas P.E., Bagley, I., Sadler, P.J., Romero-Canelon, I.
Language:en
Published: 2019
Subjects:
ROS
Anticancer complexes
Osmium complexes
Online Access:http://hdl.handle.net/10454/17070

Internet

http://hdl.handle.net/10454/17070

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