Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases

Yes === Developing new methods to treat heart diseases is always a focus for basic research and clinical applications. Existing drugs have strong side-effects and also require lifetime administration for patients. Recent attempts of using nanoparticles (NPs) in treating atherosclerosis in animals...

Full description

Bibliographic Details
Main Authors:	Zhang, J., Ma, A., Shang, Lijun
Language:	en
Published:	2018
Subjects:	Nanoparticles Gold nanoparticles Heart diseases Drugs Animal models
Online Access:	http://hdl.handle.net/10454/16530

id	ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-16530
record_format	oai_dc
spelling	ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-165302019-08-31T03:04:55Z Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases Zhang, J. Ma, A. Shang, Lijun Nanoparticles Gold nanoparticles Heart diseases Drugs Animal models Yes Developing new methods to treat heart diseases is always a focus for basic research and clinical applications. Existing drugs have strong side-effects and also require lifetime administration for patients. Recent attempts of using nanoparticles (NPs) in treating atherosclerosis in animals and some heart diseases such as heart failure and endocarditis have provided hopes for better drug delivery and reducing of drug side-effects. In this mini-review, we summarize the present applications of using gold nanoparticles (GNPs) as a new drug delivery system in diseased hearts and of the assessment of toxicity in using GNPs. We suggest that conjugating existing clinical drugs with GNPs is a favorable choice to provide “new and double-enhanced” potentiality to those existing drugs in treating heart diseases. Other applications of using NPs in the treatment of heart diseases including using drugs in nano-form and coating drugs with a surface of relevant NP are also discussed. 2018-08-07T08:42:39Z 2018-08-07T08:42:39Z 2018-05-29 2018-05-11 2018-05-29 Article published version paper Zhang J, Ma A and Shang L (2018) Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases. Frontiers in Physiology. 9:642. http://hdl.handle.net/10454/16530 en https://doi.org/10.3389/fphys.2018.00642 © 2018 Zhang, Ma and Shang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
collection	NDLTD
language	en
sources	NDLTD
topic	Nanoparticles Gold nanoparticles Heart diseases Drugs Animal models
spellingShingle	Nanoparticles Gold nanoparticles Heart diseases Drugs Animal models Zhang, J. Ma, A. Shang, Lijun Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases
description	Yes === Developing new methods to treat heart diseases is always a focus for basic research and clinical applications. Existing drugs have strong side-effects and also require lifetime administration for patients. Recent attempts of using nanoparticles (NPs) in treating atherosclerosis in animals and some heart diseases such as heart failure and endocarditis have provided hopes for better drug delivery and reducing of drug side-effects. In this mini-review, we summarize the present applications of using gold nanoparticles (GNPs) as a new drug delivery system in diseased hearts and of the assessment of toxicity in using GNPs. We suggest that conjugating existing clinical drugs with GNPs is a favorable choice to provide “new and double-enhanced” potentiality to those existing drugs in treating heart diseases. Other applications of using NPs in the treatment of heart diseases including using drugs in nano-form and coating drugs with a surface of relevant NP are also discussed.
author	Zhang, J. Ma, A. Shang, Lijun
author_facet	Zhang, J. Ma, A. Shang, Lijun
author_sort	Zhang, J.
title	Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases
title_short	Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases
title_full	Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases
title_fullStr	Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases
title_full_unstemmed	Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases
title_sort	conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases
publishDate	2018
url	http://hdl.handle.net/10454/16530
work_keys_str_mv	AT zhangj conjugatingexistingclinicaldrugswithgoldnanoparticlesforbettertreatmentofheartdiseases AT maa conjugatingexistingclinicaldrugswithgoldnanoparticlesforbettertreatmentofheartdiseases AT shanglijun conjugatingexistingclinicaldrugswithgoldnanoparticlesforbettertreatmentofheartdiseases
_version_	1719241162456301568

Conjugating existing clinical drugs with gold nanoparticles for better treatment of heart diseases

Similar Items