Synthesis of pyrimidine C-nucleoside analogues and triphosphate derivatives
Five pyrimidine C-nucleosides were prepared via Heck-type coupling reactions. These derivatives are designed to mimic dC and dU (or T). The minor groove O2 carbonyl in each derivative is replaced by a hydrogen, a fluorine, or a methyl group. The hydrogen-substituted dC analogue was converted into a...
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| Format: | Others |
| Language: | English |
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Boston College
2008
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| Online Access: | http://hdl.handle.net/2345/36 |