Identification and Characterization of PDE8 Inhibitors Using a Fission Yeast Based High-throughput Screening Platform

Identification and Characterization of PDE8 Inhibitors Using a Fission Yeast Based High-throughput Screening Platform

Thesis advisor: Charles S. Hoffman === In this thesis, I describe the development of a screening platform for detecting PDE8A inhibitors using the cAMP-dependent glucose sensing pathway of the fission yeast Schizosaccharomyces pombe, which led us to discover several PDE8A selective inhibitors. In th...

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Bibliographic Details
Main Author:	Demirbas Cakici, Didem
Format:	Others
Language:	English
Published:	Boston College 2011
Subjects:	Cyclic AMP Fission yeast High throughput screening PDE inhibitors Phosphodiesterase 8A Steroidogenesis
Online Access:	http://hdl.handle.net/2345/3051

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