Biochemical parameters of hereditary chondrodysplasia in mice
Cartilage from newborn mice homozygous for chondrodysplasia contains normal quantities of protein and chondroitin sulfate. Mutant fetal cartilage incorporates normal amounts of sulfate, glucose, and glucosamine. Overnight rinsing with water removes about 25% of the incorporated sulfur and existing u...
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| Format: | Others |
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BYU ScholarsArchive
1974
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| Online Access: | https://scholarsarchive.byu.edu/etd/7891 https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=8891&context=etd |
| Summary: | Cartilage from newborn mice homozygous for chondrodysplasia contains normal quantities of protein and chondroitin sulfate. Mutant fetal cartilage incorporates normal amounts of sulfate, glucose, and glucosamine. Overnight rinsing with water removes about 25% of the incorporated sulfur and existing uronic acid from mutant ribs and about 55% from mutant limbs. Control ribs and limbs are affected very little by such a rinse. The diffusability of chondroitin sulfate (represented by incorporated sulfur and uronic acid) may be due to a lack of covalent bond formation between chondroitin sulfate and collagen. |
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