Blockade of TGF-ß Signaling Through the Activin Type IIB Receptor with the Small Molecule, SGI-1252

Blockade of TGF-ß Signaling Through the Activin Type IIB Receptor with the Small Molecule, SGI-1252

Antagonism of the activin receptor signaling pathway represents a promising potential therapy for the muscular dystrophies and other muscle wasting disorders (i.e., cachexia or sarcopenia). Previous research has shown that antagonism of activin signaling promotes muscle growth, attenuates muscle was...

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Bibliographic Details
Main Author: Fuqua, Jordan David
Format: Others
Published: BYU ScholarsArchive 2015
Subjects:
TGF-ß
myostatin
activin
SGI-1252
Smad
phosphorylation
ALK
JAK/STAT
Exercise Science
Online Access:https://scholarsarchive.byu.edu/etd/6125
https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7125&context=etd

Internet

https://scholarsarchive.byu.edu/etd/6125
https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7125&context=etd

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