Physiologic Status Monitoring via the Gastrointestinal Tract

• Main Authors: Schwartz, S. (Contributor), Ciccarelli, Gregory A. (Contributor), Hughes, Tadd B. (Contributor), Boettcher, Tara L. (Contributor), Barman, Ross (Contributor), Swiston, Albert J., Jr (Contributor), Langer, Robert S (Author), Traverso, Carlo Giovanni (Author)
• Other Authors: Lincoln Laboratory (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Traverso, Gio (Contributor), Langer, Robert (Contributor)
• Format: Article
• Language: English
• Published: Public Library of Science, 2015-11-20T13:03:53Z.
• Subjects: Article
• Online Access: Get fulltext

Reliable, real-time heart and respiratory rates are key vital signs used in evaluating the physiological status in many clinical and non-clinical settings. Measuring these vital signs generally requires superficial attachment of physically or logistically obtrusive sensors to subjects that may result in skin irritation or adversely influence subject performance. Given the broad acceptance of ingestible electronics, we developed an approach that enables vital sign monitoring internally from the gastrointestinal tract. Here we report initial proof-of-concept large animal (porcine) experiments and a robust processing algorithm that demonstrates the feasibility of this approach. Implementing vital sign monitoring as a stand-alone technology or in conjunction with other ingestible devices has the capacity to significantly aid telemedicine, optimize performance monitoring of athletes, military service members, and first-responders, as well as provide a facile method for rapid clinical evaluation and triage.
United States. Dept. of the Air Force (Air Force Contract FA8721-05-C-0002)
United States. Dept. of Defense. Assistant Secretary of Defense for Research & Engineering
National Institutes of Health (U.S.) (Grant EB000244)
National Institutes of Health (U.S.) (Grant T32DK7191-38-S1)