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|a Gaylord, Shonda T.
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|a Harvard University-
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|a Warren, Andrew David
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|a Kwong, Gabriel A.
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|a Bhatia, Sangeeta N.
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|a Ngan, Kevin C.
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|a Dumont Milutinovic, Milena
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|a Kwong, Gabriel A.
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|a Bhatia, Sangeeta N.
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|a Walt, David R.
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|a Warren, Andrew David
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|a Disease Detection by Ultrasensitive Quantification of Microdosed Synthetic Urinary Biomarkers
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|b American Chemical Society (ACS),
|c 2015-11-10T15:08:02Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/99875
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|a The delivery of exogenous agents can enable noninvasive disease monitoring, but existing low-dose approaches require complex infrastructure. In this paper, we describe a microdose-scale injectable formulation of nanoparticles that interrogate the activity of thrombin, a key regulator of clotting, and produce urinary reporters of disease state. We establish a customized single molecule detection assay that enables urinary discrimination of thromboembolic disease in mice using doses of the nanoparticulate diagnostic agents that fall under regulatory guidelines for "microdosing."
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|a National Science Foundation (U.S.). Graduate Research Fellowship
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|a National Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award F32CA159496-02)
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|a Burroughs Wellcome Fund (Career Award at the Scientific Interface)
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|a National Cancer Institute (U.S.) (Koch Institute Support (Core) Grant P30-CA14051)
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|a David H. Koch Institute for Integrative Cancer Research at MIT (Frontier Research Program)
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|a Article
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|t Journal of the American Chemical Society
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