CRISPR transcriptional repression devices and layered circuits in mammalian cells

CRISPR transcriptional repression devices and layered circuits in mammalian cells

A key obstacle to creating sophisticated genetic circuits has been the lack of scalable device libraries. Here we present a modular transcriptional repression architecture based on clustered regularly interspaced palindromic repeats (CRISPR) system and examine approaches for regulated expression of...

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Bibliographic Details
Main Authors: Kiani, Samira (Contributor), Beal, Jacob (Author), Huh, Jin (Contributor), Xie, Zhen (Author), Li, Yinqing (Author), Weiss, Ron (Contributor), Ebrahimkhani, Mohammad Reza (Contributor), Hall, Richard N. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Synthetic Biology Center (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-10-30T17:33:13Z.
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