A bifunctional platinum(II) antitumor agent that forms DNA adducts with affinity for the estrogen receptor

A bifunctional platinum(II) antitumor agent that forms DNA adducts with affinity for the estrogen receptor

A strategy is described for the re-design of DNA damaging platinum(II) complexes to afford elevated toxicity towards cancer cells expressing the estrogen receptor (ER). Two platinum-based toxicants are described in which a DNA damaging warhead, [Pt(en)Cl[subscript 2]] (en, ethylenediamine), is tethe...

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Bibliographic Details
Main Authors: Kim, Eunsuk (Contributor), Rye, Peter T. (Contributor), Essigmann, John M. (Contributor), Croy, Robert G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-10-07T16:02:34Z.
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