2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

Compared to normal differentiated cells, cancer cells have altered metabolic regulation to support biosynthesis and the expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in this anabolic metabolism. While the M1 isoform is a highly active enzyme, the alternatively splice...

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Bibliographic Details
Main Authors:	Walsh, Martin J. (Author), Brimacombe, Kyle R. (Author), Veith, Henrike (Author), Bougie, James M. (Author), Daniel, Thomas (Author), Leister, William (Author), Cantley, Lewis C. (Author), Vander Heiden, Matthew G. (Contributor), Shen, Min (Author), Auld, Douglas S. (Author), Thomas, Craig J. (Author), Boxer, Matthew B. (Author), Israelsen, William James (Author)
Other Authors:	Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Israelsen, William J. (Contributor)
Format:	Article
Language:	English
Published:	Elsevier, 2015-10-07T15:04:46Z.
Subjects:	Article
Online Access:	Get fulltext

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