Sequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation
The influenza polymerase cleaves host RNAs ~10-13 nucleotides downstream of their 5' ends and uses this capped fragment to prime viral mRNA synthesis. To better understand this process of cap snatching, we used high-throughput sequencing to determine the 5' ends of A/WSN/33 (H1N1) influenz...
Main Authors: | Koppstein, David Neal Pira (Contributor), Bartel, David (Contributor), Ashour, Joseph (Contributor) |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor) |
Format: | Article |
Language: | English |
Published: |
Oxford University Press,
2015-05-29T12:37:01Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Insight into Influenza: A Virus Cap-Snatching
by: Corey De Vlugt, et al.
Published: (2018-11-01) -
Structural insights into reptarenavirus cap-snatching machinery.
by: Maria Rosenthal, et al.
Published: (2017-05-01) -
High-throughput sequencing of RNA 5'- and 3'-termini yields insights into viral and vertebrate gene expression
by: Koppstein, David N. P. (David Neal Pira)
Published: (2015) -
Influenza virus polymerases: determination of the cap binding site and the crucial role of CA endonuclease cleavage site in the cap snatching mechanism for the initiation of viral messenger RNA synthesis
by: Rao, Ping
Published: (2008) -
The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target
by: Wenjie Wang, et al.
Published: (2020-01-01)