Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic factors have been approved in the...

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Main Authors: Ntziachristos, Panagiotis (Author), Tsirigos, Aristotelis (Author), Welstead, G. Grant (Contributor), Trimarchi, Thomas (Author), Bakogianni, Sofia (Author), Xu, Luyao (Author), Loizou, Evangelia (Author), Holmfeldt, Linda (Author), Strikoudis, Alexandros (Author), King, Bryan (Author), Mullenders, Jasper (Author), Becksfort, Jared (Author), Nedjic, Jelena (Author), Paietta, Elisabeth (Author), Tallman, Martin S. (Author), Rowe, Jacob M. (Author), Tonon, Giovanni (Author), Satoh, Takashi (Author), Kruidenier, Laurens (Author), Prinjha, Rab (Author), Akira, Shizuo (Author), Van Vlierberghe, Pieter (Author), Ferrando, Adolfo A. (Author), Jaenisch, Rudolf (Contributor), Mullighan, Charles G. (Author), Aifantis, Iannis (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-04-30T15:32:12Z.
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