Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

Caloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust interventions known to increase longevity in lower organisms. However, little is known about the molecular adaptations induced by CR in humans. Here, we report that long-term CR in humans inhibits the IGF-1/i...

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Main Authors: Mercken, Evi M. (Author), Crosby, Seth D. (Author), Lamming, Dudley W. (Contributor), JeBailey, Lellean (Author), Krzysik-Walker, Susan (Author), Villareal, Dennis T. (Author), Capri, Miriam (Author), Franceschi, Claudio (Author), Zhang, Yongqing (Author), Becker, Kevin (Author), de Cabo, Rafael (Author), Fontana, Luigi (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2015-04-23T17:39:19Z.
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