In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

We used an in vivo small hairpin RNA (shRNA) screening approach to identify genes that are essential for MLL-AF9 acute myeloid leukemia (AML). We found that Integrin Beta 3 (Itgb3) is essential for murine leukemia cells in vivo and for human leukemia cells in xenotransplantation studies. In leukemia...

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Main Authors: Miller, Peter G (Author), Al-Shahrour, Fatima (Author), Hartwell, Kimberly A. (Author), Chu, Lisa P (Author), Jaras, Marcus (Author), Puram, Rishi V (Author), Puissant, Alexandre (Author), Callahan, Kevin P (Author), Ashton, John (Author), McConkey, Marie (Author), Poveromo, Luke P (Author), Cowley, Glenn S. (Author), Kharas, Michael G. (Author), Labelle, Myriam (Contributor), Shterental, Sebastian (Author), Fujisaki, Joji (Author), Silberstein, Lev (Author), Alexe, Gabriela (Author), Al-Hajj, Muhammad A (Author), Shelton, Christopher A (Author), Armstrong, Scott A. (Author), Root, David E (Author), Scadden, David T (Author), Mukherjee, Siddhartha (Author), Stegmaier, Kimberly (Author), Jordan, Craig T (Author), Ebert, Benjamin L. (Author), Hynes, Richard O (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Hynes, Richard O. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-04-08T18:29:38Z.
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