Widespread Regulation of Translation by Elongation Pausing in Heat Shock

Widespread Regulation of Translation by Elongation Pausing in Heat Shock

Global repression of protein synthesis is a hallmark of the cellular stress response and has been attributed primarily to inhibition of translation initiation, although this mechanism may not always explain the full extent of repression. Here, using ribosome footprinting, we show that 2 hr of severe...

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Main Authors: Shalgi, Reut (Contributor), Hurt, Jessica A. (Contributor), Krykbaeva, Irina (Contributor), Taipale, Mikko (Contributor), Lindquist, Susan (Contributor), Burge, Christopher B (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Burge, Christopher B. (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2015-03-30T19:23:30Z.
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