Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation

• Main Authors: Tsou, Yung-An (Author), Huang, Hung-Jin (Author), Wang, Tang-Chuan (Author), Tai, Chih-Jaan (Author), Chen, Chuan-Mu (Author), Chen, Calvin Yu-Chian (Contributor)
• Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor)
• Format: Article
• Language: English
• Published: Hindawi Publishing Corporation, 2015-03-20T12:41:38Z.
• Subjects: Article
• Online Access: Get fulltext

The recurrent sinonasal inverted papilloma (IP) could be transformed to sinonasal squamous cell carcinoma. We use protein expression patterns by immunohistochemical method to see whether the expression of p53, p16, p21, and p27 belongs to cell-cycle-regulators and PCNA (proliferating cell nuclear antigen) and Ki-67 the proliferation markers in sixty patients with sinonasal inverted papilloma, and 10 of them with squamous cell carcinoma transformation. Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformation of sinonasal tract compared with inverted papilloma were revealed. No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protein) and p53 expression was correlated to sinonasal IP malignant transformation by multivariate survey. However, we found elevated PLUNC expression in IPs with multiple recurrences. Finally, we found that PCNA, p27 may interact with CDK1 which promote IP cell proliferation and correlate to sinonasal squamous cell carcinoma. Ki-67 could work throughout the cell cycles to cause malignant transformation. In conclusion, this is a first study showing the correlation of Ki-67, PCNA interacted with CDK1 might lead to malignant transformation. Elevated PLUNC expression in the sinonasal IPs was related to multiple recurrences in human.
National Science Council of Taiwan (Grant NSC101-2314-B-039-013-MY3)
National Science Council of Taiwan (Grant NSC102-2325-B039-001)
National Science Council of Taiwan (Grant NSC102-2221-E-468-027)
China Medical University (Grant CMU102-BC-3)
Asia University (Grant ASIA100-CMU-2)
Asia University (Grant ASIA101-CMU-2)
Asia University (Grant 102-ASIA-07)
China Medical University Hospital (Grant DMR-102-001)
China Medical University Hospital (Grant DMR-103-025)
China Medical University Hospital (Grant DMR-103-058)
China Medical University Hospital (Grant DMR-103-001)
China Medical University Hospital (Grant DMR-103-096)