Expansion of Human Cord Blood Hematopoietic Stem Cells for Transplantation

Expansion of Human Cord Blood Hematopoietic Stem Cells for Transplantation

A recent Science paper reported a purine derivative that expands human cord blood hematopoietic stem cells in culture ( Boitano et al., 2010) by antagonizing the aryl hydrocarbon receptor. Major problems need to be overcome before ex vivo HSC expansion can be used clinically.

Bibliographic Details
Main Authors: Chou, Song (Contributor), Chu, Pat (Author), Hwang, William (Author), Lodish, Harvey F (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Lodish, Harvey F. (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2015-03-19T16:32:25Z.
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Description
Summary:A recent Science paper reported a purine derivative that expands human cord blood hematopoietic stem cells in culture ( Boitano et al., 2010) by antagonizing the aryl hydrocarbon receptor. Major problems need to be overcome before ex vivo HSC expansion can be used clinically.

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