Engineering Enzyme Specificity Using Computational Design of a Defined-Sequence Library
Engineered biosynthetic pathways have the potential to produce high-value molecules from inexpensive feedstocks, but a key limitation is engineering enzymes with high activity and specificity for new reactions. Here, we developed a method for combining structure-based computational protein design wi...
| Main Authors: | , , , , , , , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier,
2015-03-17T16:10:57Z.
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| Subjects: | |
| Online Access: | Get fulltext |