Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent

Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent

An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemothera...

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Bibliographic Details
Main Authors: Wisnovsky, Simon P (Author), Wilson, Justin J (Author), Radford, Robert J (Author), Pereira, Mark P (Author), Chan, Maria R. (Contributor), Laposa, Rebecca R (Author), Lippard, Stephen J. (Contributor), Kelley, Shana O (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor), Wilson, Justin J. (Contributor), Radford, Robert J. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-02-24T15:31:09Z.
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