Dynamic Nuclear Polarization Study of Inhibitor Binding to the M2[subscript 18-60] Proton Transporter from Influenza A

Dynamic Nuclear Polarization Study of Inhibitor Binding to the M2[subscript 18-60] Proton Transporter from Influenza A

We demonstrate the use of dynamic nuclear polarization (DNP) to elucidate ligand binding to a membrane protein using dipolar recoupling magic angle spinning (MAS) NMR. In particular, we detect drug binding in the proton transporter M2[subscript 18-60] from influenza A using recoupling experiments at...

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Bibliographic Details
Main Authors: Andreas, Loren (Contributor), Barnes, Alexander (Contributor), Chou, James J. (Author), Caporini, Marc A. (Author), Rosay, Melanie (Author), Corzilius, Bjorn (Contributor), Miller, Eric Alexander (Contributor), Griffin, Robert Guy (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology) (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2015-02-18T20:59:48Z.
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