Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System

• Main Authors: Chen, Mao (Contributor), Buchwald, Stephen Leffler (Contributor)
• Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
• Format: Article
• Language: English
• Published: Wiley Blackwell, 2015-02-06T20:03:01Z.
• Subjects: Article
• Online Access: Get fulltext

The trifluoromethylation of aryl/heteroaryl iodides has been demonstrated using a flow system, thus enabling a rapid rate of reaction. A broad spectrum of trifluoromethylated compounds was prepared in good to excellent yields using CF[subscript 3]CO[subscript 2]K as the trifluoromethyl source. The process has the advantage of short reaction times and uses convenient [CF[subscript 3]] sources.
Novartis (Firm)
National Institutes of Health (U.S.) (GM46059)