MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

We propose the Model-based Analysis of Genome-wide CRISPR/Cas9 Knockout (MAGeCK) method for prioritizing single-guide RNAs, genes and pathways in genome-scale CRISPR/Cas9 knockout screens. MAGeCK demonstrates better performance compared with existing methods, identifies both positively and negativel...

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Bibliographic Details
Main Authors: Li, Wei (Author), Xu, Han (Author), Xiao, Tengfei (Author), Cong, Le (Contributor), Love, Michael I. (Author), Zhang, Feng (Contributor), Irizarry, Rafael A. (Author), Liu, Jun S. (Author), Brown, Myles (Author), Liu, X. Shirley (Author)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: BioMed Central Ltd, 2015-01-14T16:16:10Z.
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