Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical

Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical

The development and operation of the synthesis and workup steps of a fully integrated, continuous manufacturing plant for synthesizing aliskiren, a small molecule pharmaceutical, are presented. The plant started with advanced intermediates, two synthetic steps away from the final active pharmaceutic...

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Bibliographic Details
Main Authors: Heider, Patrick L. (Contributor), Basak, Soubir (Contributor), Benyahia, Brahim (Contributor), Lakerveld, Richard (Contributor), Zhang, Haitao (Contributor), Hogan, Rachael (Contributor), Buchbinder, Louis (Contributor), Wolfe, Aaron (Contributor), Mascia, Salvatore (Contributor), Evans, James M. B. (Contributor), Jamison, Timothy F. (Contributor), Jensen, Klavs F. (Contributor), Born, Stephen (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2015-01-09T18:54:34Z.
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