Computational solutions for omics data

• Main Authors: Berger, Bonnie (Contributor), Peng, Jian (Contributor), Singh, Mona (Author)
• Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Mathematics (Contributor)
• Format: Article
• Language: English
• Published: Nature Publishing Group, 2014-12-19T19:39:10Z.
• Subjects: Article
• Online Access: Get fulltext

High-throughput experimental technologies are generating increasingly massive and complex genomic data sets. The sheer enormity and heterogeneity of these data threaten to make the arising problems computationally infeasible. Fortunately, powerful algorithmic techniques lead to software that can answer important biomedical questions in practice. In this Review, we sample the algorithmic landscape, focusing on state-of-the-art techniques, the understanding of which will aid the bench biologist in analysing omics data. We spotlight specific examples that have facilitated and enriched analyses of sequence, transcriptomic and network data sets.
National Institutes of Health (U.S.) (Grant GM081871)